The above statement of not needing any special middleware only applies to using your smartcard to logon to Windows 7 or 2008 R2. The software and drivers available from Microsoft do not handle multiple concurrent requests such as the ones that occur with SharePoint 2007/2010 sites secured with client certificates. You will still be able to use your smart card, but will be prompted multiple times as other resources load, such as javascript, stylesheets, or images. This occurs once per resource
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